NRM

Across TCGA cell cohorts, NRM mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NRM-associated genes across cancer lineages are DEFA1B and SERPINB13. Each is linked with NRM in more than 1 cancer types. Because this analysis shows association rather than direction, both NRM-to-partner and partner-to-NRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA1B grouped by NRM-low versus NRM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRM→partner) and Y-score (partner→NRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFA1B →	+2.239	+3.922	<.001	.002	3	1
BLOOD_Leukemia	SERPINB13 →	+0.053	+3.696	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

DEFA1B by NRM expression — BLOOD_Leukemia

Explore this box plot interactively →