NRL

Across TCGA cell cohorts, NRL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,035 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NRL-associated GO terms across cancer lineages are Protein linear polyubiquitination, Regulation of protein localization to endoplasmic reticulum, and Positive regulation of gene expression, epigenetic. Each is linked with NRL in more than 9 cancer types. Because this analysis shows association rather than direction, both NRL-to-partner and partner-to-NRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein linear polyubiquitination grouped by NRL-low versus NRL-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NRL→partner) and Y-score (partner→NRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Protein linear polyubiquitination →	+0.121	+0.382	<.001	<.001	3	10
KIDNEY	Regulation of protein localization to endoplasmic reticulum →	+0.100	+0.144	.007	.004	3	9
OESOPHAGUS	Positive regulation of gene expression, epigenetic →	+0.076	+0.647	.001	<.001	3	9
LUNG_SCLC	Positive regulation of stem cell population maintenance →	+0.096	+0.842	.005	<.001	3	9
URINARY_TRACT	Negative regulation of protein localization to chromatin →	+0.123	+0.564	.002	.001	2	9
OESOPHAGUS	Transcription initiation-coupled chromatin remodeling →	+0.085	+0.660	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,035 associations by consensus.

Protein linear polyubiquitination by NRL expression — OVARY

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