NRL

Across TCGA pan-cancer cohorts, NRL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NRL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NRL RNA is repressed in tumor relative to normal tissue. In most cancer types NRL is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where NRL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.890	<.001	12	view →
THCA	Male	III,IV	−1.092	<.001	9	view →
LUSC	All	III,IV	−0.655	<.001	9	view →
KIRP	All	All	−0.509	<.001	9	view →
LUAD	Female	III,IV	−0.495	<.001	9	view →
LIHC	All	All	+0.268	.001	5	view →
KICH	All	All	−0.521	.005	4	view →
HNSC	All	III,IV	+0.253	.013	3	view →
PRAD	All	All	−0.140	.003	2	view →
BLCA	Male	IV	−0.282	.049	1	view →
STAD	All	II,III,IV	+0.213	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NRL–KIRC

Open the KIRC breakdown →