NRIP2

Across TCGA patient cohorts, NRIP2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRIP2-associated genes across cancer lineages are ASNS, ERK2, and GATA6. Each is linked with NRIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRIP2-to-partner and partner-to-NRIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NRIP2-low versus NRIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRIP2→partner) and Y-score (partner→NRIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.455	+3.169	.006	.019	3	2
UCEC	ERK2 →	+0.250	+2.999	.005	.035	3	1
UCEC	GATA6 →	-0.197	-2.985	.006	.034	3	1
UCEC	Heregulin →	-0.159	-2.459	.005	.019	3	1
UCEC	Mre11 →	-0.128	-2.584	.001	.011	3	1
UCEC	Paxillin →	+0.323	+2.331	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ASNS by NRIP2 expression — UCEC

Explore this box plot interactively →