NRIP2

Across TCGA pan-cancer cohorts, NRIP2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NRIP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NRIP2 RNA is repressed in tumor relative to normal tissue. In most cancer types NRIP2 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and KICH are the cancer types where NRIP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRIP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−1.746	<.001	11	view →
THCA	All	III,IV	−0.980	<.001	11	view →
KICH	All	III,IV	−1.428	<.001	9	view →
LIHC	Female	All	+1.230	<.001	9	view →
LUAD	Male	III,IV	−0.774	<.001	9	view →
BLCA	Male	III,IV	−1.115	.002	8	view →
UCEC	All	All	−1.931	<.001	6	view →
BRCA	All	II,III,IV	−0.982	<.001	6	view →
CHOL	All	All	+1.808	<.001	5	view →
LUSC	Male	All	−0.514	<.001	4	view →
COAD	All	All	−0.305	.022	3	view →
KIRC	Female	All	+0.721	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NRIP2–KIRP

Open the KIRP breakdown →