Across TCGA patient cohorts, NRG3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,650 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NRG3-associated proteins across cancer lineages are THY1, EEF2, and PPP1R9A_S840. Each is linked with NRG3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NRG3-to-partner and partner-to-NRG3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG3→partner) and Y-score (partner→NRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THY1 →	+0.751	+1.032	<.001	<.001	3	4
GBM	EEF2 →	-0.221	-1.057	<.001	<.001	3	4
HNSC	PPP1R9A_S840 →	+2.008	+0.558	<.001	.004	3	4
LSCC	DDAH1 →	+0.634	+0.368	<.001	.001	3	4
GBM	STXBP6 →	+0.780	+1.092	<.001	<.001	3	4
CCRCC	RPS8 →	-0.314	-0.878	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,650 associations by consensus.

Exploration

NRG3 survival (RNA) · tumor vs normal (RNA) · all NRG3 data types