Across TCGA patient cohorts, NRG3 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRG3-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and Akt_pS473. Each is linked with NRG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRG3-to-partner and partner-to-NRG3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG3→partner) and Y-score (partner→NRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.268	+1.882	.009	.031	3	3
COAD	Caspase-7-cleavedD198 →	+1.328	+3.338	<.001	.004	3	3
STAD	Akt_pS473 →	-0.406	-3.169	.038	.019	3	2
COAD	EGFR_pY1068 →	-0.415	-3.169	.002	.017	3	2
UCEC	ERCC1 →	-0.100	-2.089	.048	.016	3	2
UCEC	FASN →	+0.261	+2.321	.024	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

NRG3 survival (RNA) · tumor vs normal (RNA) · all NRG3 data types