Across TCGA cell cohorts, NRG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,849 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NRG3-associated GO terms across cancer lineages are Ribonucleoside triphosphate biosynthetic process, Transport along microtubule, and Regulation of tumor necrosis factor production. Each is linked with NRG3 in more than 4 cancer types. Because this analysis shows association rather than direction, both NRG3-to-partner and partner-to-NRG3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG3→partner) and Y-score (partner→NRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Ribonucleoside triphosphate biosynthetic process →	+0.104	+0.461	<.001	.009	3	5
KIDNEY	Transport along microtubule →	+0.037	+0.780	.006	.008	3	5
BREAST	Regulation of tumor necrosis factor production →	-0.064	-0.369	.003	.009	3	5
SKIN	Cardiolipin metabolic process →	+0.087	+1.302	<.001	<.001	3	5
SKIN	Regulation of tumor necrosis factor superfamily cytokine production →	-0.065	-1.361	<.001	<.001	3	5
BONE	Positive regulation of RNA export from nucleus →	+0.101	+0.557	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,849 associations by consensus.

Exploration

NRG3 survival (RNA) · tumor vs normal (RNA) · all NRG3 data types