NRG2

Across TCGA patient cohorts, NRG2 mutation is significantly associated with the RNA expression of many other genes, with 4,044 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRG2-associated genes across cancer lineages are MIR4686, CSPG4P3Y, and RNU6-591P. Each is linked with NRG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRG2-to-partner and partner-to-NRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4686 grouped by NRG2-low versus NRG2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG2→partner) and Y-score (partner→NRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	MIR4686 →	+0.838	+7.939	<.001	.008	3	3
PRAD	CSPG4P3Y →	+0.009	+7.939	<.001	.008	3	2
PRAD	RNU6-591P →	+0.304	+7.939	<.001	.008	3	2
LUAD	S100A11P9 →	+0.585	+3.690	<.001	.009	3	2
SKCM	ACTR3B →	+0.690	+2.604	<.001	.006	3	2
UCEC	RN7SL248P →	+0.059	+3.137	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,044 associations by consensus.

MIR4686 by NRG2 expression — PRAD

Explore this box plot interactively →