NRG1-IT3

Across TCGA pan-cancer cohorts, NRG1-IT3 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated NRG1-IT3 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NRG1-IT3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRG1-IT3 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

KIRC, HNSC, and STAD are the cancer types where NRG1-IT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.141	0.759	<.001	84	view →
HNSC	DFS	Tertile	All	0.215	0.629	.010	45	view →
STAD	OS	Tertile	II,III,IV	0.159	0.566	.012	27	view →
THYM	OS	Tertile	All	0.352	0.884	.008	24	view →
UCEC	DFS	Tertile	IV	0.206	0.704	.033	24	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
ESCA	OS	Tertile	III,IV	1.000	0.368	.023	18	view →
LAML	DFS	Tertile	All	0.056	0.572	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NRG1-IT3–KIRC (DFS)

Open the KIRC breakdown →