NRG1-IT3

Across TCGA pan-cancer cohorts, NRG1-IT3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of NRG1-IT3’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where NRG1-IT3 RNA is repressed in tumor relative to normal tissue. In most cancer types NRG1-IT3 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA are the cancer types where NRG1-IT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRG1-IT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.007	.047	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

NRG1-IT3–BRCA

Open the BRCA breakdown →