NRG1-IT1

Across TCGA pan-cancer cohorts, NRG1-IT1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated NRG1-IT1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NRG1-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NRG1-IT1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRP show a favorable association.

COAD, DLBC, and UVM are the cancer types where NRG1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	IV	0.183	0.670	.003	54	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	33	view →
SKCM	DFS	Tertile	III,IV	0.486	0.219	.013	21	view →
CHOL	DFS	Quartile	All	0.294	0.835	.021	18	view →
BLCA	DFS	Tertile	IV	0.164	0.485	.020	18	view →
LAML	DFS	Tertile	All	0.214	0.582	.042	18	view →
LIHC	DFS	Tertile	All	0.187	0.317	.022	18	view →
KIRP	DFS	Tertile	All	1.000	0.833	.026	11	view →
LGG	OS	Tertile	All	0.255	0.550	.031	9	view →
THCA	OS	Tertile	All	0.240	0.931	.009	9	view →
ESCA	DFS	Tertile	All	1.000	0.572	.029	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

NRG1-IT1–COAD (OS)

Open the COAD breakdown →