NRG1-IT1

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, NRG1-IT1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NRG1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where NRG1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NRG1-IT1 is over-expressed in tumor.

LUSC and LIHC are the cancer types where NRG1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRG1-IT1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
LUSCAllAll+0.055.0134view →
LIHCAllAll+0.055.0262view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

NRG1-IT1–LUSC

Tumor-vs-normal expression box plot for NRG1-IT1 RNA in LUSC.

Open the LUSC breakdown →

Exploration