NRF1

Across TCGA pan-cancer cohorts, NRF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NRF1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NRF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NRF1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where NRF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.912	0.710	.009	29	view →
UCEC	OS	Tertile	II,III,IV	0.480	1.000	.012	20	view →
LSCC	OS	Quartile	All	0.902	0.667	.017	8	view →
PDAC	OS	Median	All	0.720	0.965	.023	4	view →
HNSC	OS	Median	III,IV	0.800	0.925	.019	2	view →
LUAD	DFS	Tertile	II,III,IV	0.818	0.963	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NRF1–CCRCC (OS)

Open the CCRCC breakdown →