NREP

Across TCGA patient cohorts, NREP mutation is significantly associated with the RNA expression of many other genes, with 751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NREP-associated genes across cancer lineages are RNU6-13P, ATP5IF1, and DPP9. Each is linked with NREP in more than 1 cancer types. Because this analysis shows association rather than direction, both NREP-to-partner and partner-to-NREP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by NREP-low versus NREP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NREP→partner) and Y-score (partner→NREP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-13P →	+0.213	+1.944	.002	.004	3	2
UCEC	ATP5IF1 →	+0.376	+3.595	.003	.001	3	2
UCEC	DPP9 →	+0.464	+2.970	<.001	<.001	3	2
UCEC	RNA5SP113 →	+0.396	+2.766	<.001	.003	3	2
UCEC	CWC25 →	+0.405	+3.960	.001	<.001	3	1
UCEC	TAF9 →	+0.565	+2.928	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 751 associations by consensus.

RNU6-13P by NREP expression — UCEC

Explore this box plot interactively →