NREP

Across TCGA pan-cancer cohorts, NREP RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NREP data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NREP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NREP expression acts as an unfavorable survival marker, although some lineages such as KIRC and LAML show a favorable association.

KIRC, MESO, and LIHC are the cancer types where NREP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.745	0.515	.001	101	view →
MESO	OS	Median	All	0.280	0.487	.001	73	view →
LIHC	OS	Median	II,III,IV	0.557	0.806	<.001	71	view →
ACC	OS	Tertile	All	0.292	0.807	<.001	70	view →
STAD	OS	Tertile	All	0.489	0.680	.002	55	view →
BLCA	DFS	Quartile	All	0.484	0.776	.002	50	view →
UVM	OS	Median	III,IV	0.246	0.836	.003	45	view →
CESC	DFS	Median	All	0.434	0.640	.003	32	view →
KICH	OS	Median	All	0.705	1.000	.006	27	view →
LAML	DFS	Quartile	All	0.720	0.414	.001	26	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	24	view →
THCA	OS	Median	All	0.823	1.000	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NREP–KIRC (DFS)

Open the KIRC breakdown →