NREP

Across TCGA patient cohorts, NREP mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NREP-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and HSP70. Each is linked with NREP in more than 1 cancer types. Because this analysis shows association rather than direction, both NREP-to-partner and partner-to-NREP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NREP-low versus NREP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NREP→partner) and Y-score (partner→NREP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.088	-2.295	.019	.033	3	1
UCEC	EGFR_pY1068 →	-0.264	-2.321	.005	.005	3	1
UCEC	HSP70 →	-0.350	-1.690	.020	.042	3	1
UCEC	INPP4B →	-0.284	-2.459	.019	.018	3	1
UCEC	JNK2 →	+0.296	+3.611	<.001	.001	3	1
UCEC	Ku80 →	+0.307	+3.009	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

14-3-3_beta by NREP expression — UCEC

Explore this box plot interactively →