NRDC

Across TCGA patient cohorts, NRDC mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRDC-associated genes across cancer lineages are ASNS, ATM, and eEF2. Each is linked with NRDC in more than 3 cancer types. Because this analysis shows association rather than direction, both NRDC-to-partner and partner-to-NRDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NRDC-low versus NRDC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRDC→partner) and Y-score (partner→NRDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.434	+1.874	<.001	.002	3	4
UCEC	ATM →	-0.502	-2.986	<.001	<.001	3	3
BLCA	eEF2 →	+0.373	+3.017	.003	.019	3	2
UCEC	EGFR_pY1068 →	-0.252	-3.087	<.001	<.001	3	2
UCEC	eIF4E →	+0.133	+1.637	.032	.001	3	2
UCEC	p62 Lck ligand →	+0.305	+2.999	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ASNS by NRDC expression — UCEC

Explore this box plot interactively →