NRDC

Across TCGA pan-cancer cohorts, NRDC RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NRDC data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher NRDC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRDC expression acts as an unfavorable survival marker, although some lineages such as ESCA and GBM show a favorable association.

MESO, KICH, and KIRP are the cancer types where NRDC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.264	0.460	<.001	141	view →
KICH	OS	Median	II,III,IV	0.624	1.000	<.001	105	view →
KIRP	DFS	Median	All	0.781	0.923	<.001	98	view →
ACC	DFS	Tertile	All	0.377	0.794	<.001	88	view →
BLCA	DFS	Median	II,III,IV	0.454	0.560	.003	79	view →
UVM	DFS	Tertile	III,IV	0.201	0.638	.007	59	view →
LGG	DFS	Median	All	0.642	0.844	<.001	54	view →
LIHC	DFS	Median	All	0.452	0.630	<.001	53	view →
SARC	DFS	Median	All	0.527	0.689	<.001	33	view →
LUAD	OS	Median	All	0.774	0.886	<.001	28	view →
HNSC	OS	Median	II,III,IV	0.301	0.435	.013	23	view →
KIRC	DFS	Tertile	IV	0.312	0.592	.009	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NRDC–MESO (DFS)

Open the MESO breakdown →