NRDC

Across TCGA cell cohorts, NRDC mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRDC-associated genes across cancer lineages are TXNDC17, MRPL17, and GPX4. Each is linked with NRDC in more than 1 cancer types. Because this analysis shows association rather than direction, both NRDC-to-partner and partner-to-NRDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNDC17 grouped by NRDC-low versus NRDC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRDC→partner) and Y-score (partner→NRDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TXNDC17 →	+0.756	+3.212	.003	.006	3	2
LARGE_INTESTINE	MRPL17 →	+0.499	+3.212	.001	.006	3	2
LARGE_INTESTINE	GPX4 →	+0.501	+3.064	.008	.009	3	2
LARGE_INTESTINE	MINPP1 →	+0.647	+3.299	.001	.004	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.016	+3.212	.001	.006	3	1
LARGE_INTESTINE	KCNJ5 →	+0.989	+3.485	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

TXNDC17 by NRDC expression — LARGE_INTESTINE

Explore this box plot interactively →