NRCAM

Across TCGA cell cohorts, NRCAM mutation is significantly associated with the RNA expression of many other genes, with 737 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRCAM-associated genes across cancer lineages are TMCO2, OC90, and OR6J1. Each is linked with NRCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both NRCAM-to-partner and partner-to-NRCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO2 grouped by NRCAM-low versus NRCAM-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRCAM→partner) and Y-score (partner→NRCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMCO2 →	+0.065	+2.748	<.001	.006	3	2
LUNG_NSCLC_LUAD	OC90 →	+0.010	+3.108	<.001	.001	3	2
LUNG_NSCLC_LUAD	OR6J1 →	+0.026	+3.700	.003	.001	3	2
SKIN	IAPP →	+0.062	+2.791	.006	.005	3	2
LARGE_INTESTINE	CRBN →	+0.444	+3.710	<.001	<.001	3	2
LARGE_INTESTINE	ORC2 →	+0.519	+3.295	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 737 associations by consensus.

TMCO2 by NRCAM expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →