NRCAM

Across TCGA pan-cancer cohorts, NRCAM RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NRCAM’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NRCAM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NRCAM is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

THCA, BLCA, and LIHC are the cancer types where NRCAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRCAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	III,IV	+2.558	<.001	11	view →
BLCA	All	All	+1.527	<.001	10	view →
LIHC	Male	II,III,IV	+2.718	<.001	8	view →
UCEC	All	All	+1.773	<.001	6	view →
LUSC	All	All	+1.685	<.001	6	view →
HNSC	All	All	+0.839	.001	6	view →
STAD	All	All	+0.695	.009	4	view →
BRCA	All	II,III,IV	+0.426	.006	4	view →
LUAD	Female	III,IV	−0.886	.005	3	view →
COAD	All	II,III,IV	+0.472	.027	3	view →
CHOL	All	All	+1.446	.007	2	view →
READ	Male	All	+1.193	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NRCAM–THCA

Open the THCA breakdown →