NR6A1

Across TCGA patient cohorts, NR6A1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR6A1-associated genes across cancer lineages are Caspase-7-cleavedD198, GATA6, and JNK2. Each is linked with NR6A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR6A1-to-partner and partner-to-NR6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NR6A1-low versus NR6A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR6A1→partner) and Y-score (partner→NR6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.601	+2.189	.029	.034	3	3
UCEC	GATA6 →	-0.164	-2.321	.028	.034	3	1
UCEC	JNK2 →	+0.300	+3.700	.001	.001	3	1
UCEC	mTOR_pS2448 →	-0.166	-2.986	.017	.035	3	1
UCEC	PDCD4 →	-0.621	-2.999	.004	.035	3	1
UCEC	Smad3 →	+0.163	+2.459	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by NR6A1 expression — UCEC

Explore this box plot interactively →