NR4A3

Across TCGA pan-cancer cohorts, NR4A3 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NR4A3 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher NR4A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NR4A3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, COAD, and UCEC are the cancer types where NR4A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.084	0.844	<.001	36	view →
COAD	OS	Median	II,III,IV	0.234	0.789	<.001	27	view →
UCEC	DFS	Median	II,III,IV	0.922	0.437	.023	10	view →
SARC	DFS	Median	All	0.133	0.613	.004	6	view →
HNSC	OS	Median	III,IV	0.155	0.656	.022	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	DFS	Median	All	0.104	0.555	.003	6	view →
SKCM	DFS	Median	All	0.192	0.757	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NR4A3–OV (OS)

Open the OV breakdown →