NR4A3

Across TCGA pan-cancer cohorts, NR4A3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NR4A3’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where NR4A3 RNA is repressed in tumor relative to normal tissue. In most cancer types NR4A3 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and KIRP are the cancer types where NR4A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NR4A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−3.742	<.001	11	view →
KICH	All	III,IV	−3.257	<.001	11	view →
KIRP	Male	II,III,IV	−3.001	<.001	11	view →
LIHC	Male	All	−1.236	<.001	9	view →
THCA	Female	All	−2.024	<.001	8	view →
LUAD	Male	All	−1.895	<.001	8	view →
KIRC	All	III,IV	−1.206	<.001	8	view →
LUSC	Male	II,III,IV	−3.091	<.001	6	view →
UCEC	All	II,III,IV	−2.729	<.001	6	view →
BRCA	All	III,IV	−2.229	<.001	6	view →
PRAD	All	All	−1.065	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NR4A3–BLCA

Open the BLCA breakdown →