NR4A3

Across TCGA patient cohorts, NR4A3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR4A3-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and FoxM1. Each is linked with NR4A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NR4A3-to-partner and partner-to-NR4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NR4A3-low versus NR4A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A3→partner) and Y-score (partner→NR4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.477	+1.678	.008	.019	3	4
UCEC	eIF4E →	+0.132	+1.473	.040	.006	3	2
UCEC	FoxM1 →	+0.166	+1.473	.036	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.173	-2.209	<.001	<.001	3	2
UCEC	JNK2 →	+0.182	+1.512	.002	.017	3	2
UCEC	mTOR_pS2448 →	-0.107	-1.745	.019	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by NR4A3 expression — UCEC

Explore this box plot interactively →