NR4A1AS

Across TCGA pan-cancer cohorts, NR4A1AS RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NR4A1AS data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher NR4A1AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NR4A1AS expression acts as an unfavorable survival marker, although some lineages such as KICH and BRCA show a favorable association.

UVM, COAD, and KICH are the cancer types where NR4A1AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.410	0.731	<.001	106	view →
COAD	DFS	Median	III,IV	0.213	0.727	.001	48	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.596	.003	31	view →
BRCA	OS	Quartile	III,IV	0.759	0.461	.003	25	view →
LUSC	DFS	Tertile	II,III,IV	0.266	0.456	.002	25	view →
LIHC	DFS	Median	III,IV	0.509	0.204	.007	20	view →
CHOL	DFS	Tertile	All	0.697	0.185	.017	9	view →
ACC	OS	Tertile	III,IV	0.568	0.929	.026	9	view →
LUAD	OS	Tertile	All	0.753	0.629	.006	9	view →
BLCA	OS	Median	All	0.353	0.480	.027	8	view →
THCA	OS	Tertile	All	0.970	1.000	.018	8	view →
READ	OS	Quartile	III,IV	1.000	0.614	.009	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NR4A1AS–UVM (DFS)

Open the UVM breakdown →