NR4A1AS

Across TCGA pan-cancer cohorts, NR4A1AS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NR4A1AS’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where NR4A1AS RNA is repressed in tumor relative to normal tissue. In most cancer types NR4A1AS is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KIRP are the cancer types where NR4A1AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NR4A1AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	IV	−2.680	<.001	12	view →
THCA	All	III,IV	−1.885	<.001	11	view →
KIRP	Male	All	−1.830	<.001	11	view →
KICH	All	III,IV	−1.887	<.001	10	view →
HNSC	All	All	−0.495	.001	9	view →
UCEC	All	II,III,IV	−2.824	<.001	8	view →
KIRC	Male	II,III,IV	−0.780	<.001	8	view →
LUAD	Female	All	−1.031	<.001	7	view →
LUSC	Female	All	−1.719	<.001	6	view →
BRCA	All	III,IV	−1.573	<.001	6	view →
LIHC	All	All	−0.192	.006	3	view →
ESCA	All	All	+0.660	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NR4A1AS–BLCA

Open the BLCA breakdown →