NR4A1

Across TCGA patient cohorts, NR4A1 mutation is significantly associated with the RNA expression of many other genes, with 993 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR4A1-associated genes across cancer lineages are RN7SL495P, RNU6-15P, and MTCYBP45. Each is linked with NR4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR4A1-to-partner and partner-to-NR4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL495P grouped by NR4A1-low versus NR4A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A1→partner) and Y-score (partner→NR4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL495P →	+0.073	+2.833	.006	.009	3	2
CESC	RNU6-15P →	+0.532	+4.364	<.001	.006	3	2
CESC	MTCYBP45 →	+0.156	+4.934	<.001	.002	3	2
LUSC	KSR1P1 →	+0.334	+3.091	<.001	.007	3	2
UCEC	DDX19A →	+0.396	+2.021	.006	.005	3	2
UCEC	RN7SL376P →	+0.148	+1.788	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 993 associations by consensus.

RN7SL495P by NR4A1 expression — UCEC

Explore this box plot interactively →