NR4A1

Across TCGA cell cohorts, NR4A1 mutation is significantly associated with the RNA expression of many other genes, with 498 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR4A1-associated genes across cancer lineages are MTRNR2L6, CLEC4M, and OR1L6. Each is linked with NR4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR4A1-to-partner and partner-to-NR4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by NR4A1-low versus NR4A1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR4A1→partner) and Y-score (partner→NR4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	2
LUNG_NSCLC_LUAD	CLEC4M →	+0.053	+3.807	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.022	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

MTRNR2L6 by NR4A1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →