NR3C1

Across TCGA patient cohorts, NR3C1 mutation is significantly associated with the RNA expression of many other genes, with 3,315 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR3C1-associated genes across cancer lineages are RNU6-839P, HMGB3P23, and MIRLET7BHG. Each is linked with NR3C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR3C1-to-partner and partner-to-NR3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-839P grouped by NR3C1-low versus NR3C1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR3C1→partner) and Y-score (partner→NR3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-839P →	+0.172	+7.471	<.001	.008	3	3
LUAD	HMGB3P23 →	+0.042	+4.912	<.001	.003	3	3
UCEC	MIRLET7BHG →	+0.350	+1.668	<.001	.003	3	3
UCEC	TRAJ57 →	+0.347	+1.931	<.001	<.001	3	3
LIHC	H3P42 →	+0.085	+5.033	.004	.009	3	2
UCEC	ATP5F1A →	+0.300	+1.530	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,315 associations by consensus.

RNU6-839P by NR3C1 expression — BRCA

Explore this box plot interactively →