NR3C1

Across TCGA cell cohorts, NR3C1 mutation is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NR3C1-associated genes across cancer lineages are CBLN4, MAGEB5, and AVP. Each is linked with NR3C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR3C1-to-partner and partner-to-NR3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLN4 grouped by NR3C1-low versus NR3C1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR3C1→partner) and Y-score (partner→NR3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CBLN4 →	+0.002	+3.316	<.001	.003	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	VN1R2 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.023	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

CBLN4 by NR3C1 expression — BLOOD_Leukemia

Explore this box plot interactively →