NR2F1-AS1

Across TCGA pan-cancer cohorts, NR2F1-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NR2F1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NR2F1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NR2F1-AS1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KICH, and KIRP are the cancer types where NR2F1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NR2F1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.777	<.001	12	view →
KICH	Female	All	−1.795	<.001	11	view →
KIRP	Female	All	−1.396	<.001	11	view →
KIRC	All	II,III,IV	−0.827	<.001	11	view →
THCA	Male	III,IV	+2.605	<.001	10	view →
UCEC	All	III,IV	−1.803	<.001	8	view →
BLCA	All	All	−0.766	.005	7	view →
LUSC	All	II,III,IV	−0.611	<.001	7	view →
BRCA	All	All	−0.474	<.001	6	view →
LIHC	All	II,III,IV	+0.430	.002	6	view →
STAD	All	All	−0.673	.004	4	view →
PRAD	All	All	−0.359	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NR2F1-AS1–HNSC

Open the HNSC breakdown →