Across TCGA pan-cancer cohorts, NR2C2AP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NR2C2AP data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NR2C2AP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NR2C2AP expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where NR2C2AP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.797	0.939	.008	12	view →
GBM	DFS	Median	All	0.245	0.500	.006	6	view →
CCRCC	OS	Quartile	II,III,IV	0.556	0.831	.029	3	view →
LUAD	DFS	Median	All	0.878	0.531	.015	3	view →
UCEC	DFS	Quartile	All	0.965	0.764	.024	2	view →
PDAC	OS	Tertile	III,IV	0.500	1.000	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: NR2C2AP tumor-vs-normal RNA expression · all NR2C2AP data types