NR2C1

Across TCGA pan-cancer cohorts, NR2C1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NR2C1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NR2C1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NR2C1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where NR2C1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.969	0.787	<.001	26	view →
CCRCC	OS	Median	II,III,IV	0.277	1.000	.005	13	view →
PDAC	DFS	Median	All	0.310	1.000	.011	10	view →
LUAD	DFS	Tertile	All	0.895	0.386	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NR2C1–LSCC (OS)

Open the LSCC breakdown →