NR2C1

Across TCGA patient cohorts, NR2C1 mutation is significantly associated with the RNA expression of many other genes, with 622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR2C1-associated genes across cancer lineages are FGF6, PDE4DIPP8, and TRGJP2. Each is linked with NR2C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2C1-to-partner and partner-to-NR2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by NR2C1-low versus NR2C1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2C1→partner) and Y-score (partner→NR2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	FGF6 →	+0.075	+5.127	<.001	.001	3	2
CESC	PDE4DIPP8 →	+0.063	+4.669	<.001	.007	3	2
UCEC	TRGJP2 →	+0.485	+2.058	<.001	.001	3	2
UCEC	TRDV3 →	+0.334	+1.857	<.001	.001	3	2
UCEC	INTS4 →	+0.304	+2.917	.005	<.001	3	1
UCEC	ME3 →	-0.898	-2.978	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 622 associations by consensus.

FGF6 by NR2C1 expression — CESC

Explore this box plot interactively →