NR2C1

Across TCGA patient cohorts, NR2C1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR2C1-associated genes across cancer lineages are TIGAR, Cyclin-B1, and A-Raf_pS299. Each is linked with NR2C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR2C1-to-partner and partner-to-NR2C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by NR2C1-low versus NR2C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR2C1→partner) and Y-score (partner→NR2C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.182	+1.704	.001	.013	3	2
UCEC	Cyclin-B1 →	+0.703	+3.459	.001	.005	3	2
UCEC	A-Raf_pS299 →	-0.142	-3.584	.001	.002	3	1
UCEC	Gab2 →	+0.374	+1.678	.006	.023	3	1
UCEC	IGFBP2 →	-0.520	-1.678	.037	.023	3	1
UCEC	ACVRL1 →	-0.118	-2.308	.024	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TIGAR by NR2C1 expression — UCEC

Explore this box plot interactively →