NR1I3

Across TCGA patient cohorts, NR1I3 mutation is significantly associated with the RNA expression of many other genes, with 1,488 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1I3-associated genes across cancer lineages are SHCBP1, ELMO2P1, and CHEK1. Each is linked with NR1I3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NR1I3-to-partner and partner-to-NR1I3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1 grouped by NR1I3-low versus NR1I3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1I3→partner) and Y-score (partner→NR1I3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHCBP1 →	+0.592	+3.332	.003	.005	3	3
UCEC	ELMO2P1 →	+0.115	+1.847	.002	.004	3	2
UCEC	CHEK1 →	+0.621	+3.343	.002	.005	3	2
UCEC	SKA1 →	+0.699	+2.724	.001	.003	3	2
UCEC	PKN3 →	+0.666	+3.180	<.001	<.001	3	2
UCEC	DTYMK →	+0.480	+2.931	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,488 associations by consensus.

SHCBP1 by NR1I3 expression — UCEC

Explore this box plot interactively →