NR1I3

Across TCGA pan-cancer cohorts, NR1I3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NR1I3 data layer compared with 7 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NR1I3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NR1I3 expression acts as an unfavorable survival marker, although some lineages such as SARC and HNSC show a favorable association.

ACC, BRCA, and UCEC are the cancer types where NR1I3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.242	0.655	<.001	91	view →
BRCA	OS	Median	II,III,IV	0.475	0.641	.004	65	view →
UCEC	DFS	Tertile	All	0.624	0.775	<.001	58	view →
CHOL	DFS	Tertile	II,III,IV	0.122	0.575	.001	43	view →
SARC	OS	Median	All	0.821	0.664	<.001	30	view →
LUAD	DFS	Quartile	IV	0.466	0.903	.030	18	view →
UVM	DFS	Quartile	All	0.177	0.887	.003	16	view →
COAD	DFS	Quartile	II,III,IV	0.317	0.730	.007	14	view →
HNSC	DFS	Tertile	III,IV	0.328	0.216	.012	14	view →
THCA	OS	Quartile	III,IV	0.933	1.000	.011	12	view →
LUSC	OS	Tertile	All	0.535	0.306	.015	11	view →
LIHC	OS	Median	III,IV	0.739	0.478	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NR1I3–ACC (DFS)

Open the ACC breakdown →