NR1I3

Across TCGA patient cohorts, NR1I3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1I3-associated genes across cancer lineages are TFRC, JNK2, and Myosin-IIa_pS1943. Each is linked with NR1I3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1I3-to-partner and partner-to-NR1I3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by NR1I3-low versus NR1I3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1I3→partner) and Y-score (partner→NR1I3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.556	+2.000	.020	.032	3	2
UCEC	JNK2 →	+0.266	+2.000	.002	.032	3	1
UCEC	Myosin-IIa_pS1943 →	+0.195	+2.321	.036	.034	3	1
UCEC	Myosin-IIa →	+0.171	+2.818	.048	.035	3	1
UCEC	p70-S6K →	+0.186	+2.999	.032	.035	3	1
UCEC	PRAS40_pT246 →	+0.154	+3.000	.046	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TFRC by NR1I3 expression — UCEC

Explore this box plot interactively →