NR1I2

Across TCGA patient cohorts, NR1I2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1I2-associated genes across cancer lineages are EGFR_pY1068, EGFR, and ERK2. Each is linked with NR1I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1I2-to-partner and partner-to-NR1I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NR1I2-low versus NR1I2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1I2→partner) and Y-score (partner→NR1I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-3.169	.021	.019	3	1
UCEC	EGFR →	-0.189	-2.973	.006	.035	3	1
UCEC	ERK2 →	+0.240	+2.459	.004	.019	3	1
UCEC	Heregulin →	-0.121	-2.459	.024	.019	3	1
UCEC	INPP4B →	-0.372	-3.584	.008	.002	3	1
UCEC	JNK2 →	+0.304	+2.115	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by NR1I2 expression — UCEC

Explore this box plot interactively →