NR1H4

Across TCGA pan-cancer cohorts, NR1H4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NR1H4 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NR1H4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NR1H4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, OV, and SCLC are the cancer types where NR1H4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.974	0.826	.011	30	view →
OV	DFS	Median	All	0.104	0.541	<.001	18	view →
SCLC	OS	Median	III,IV	0.082	0.639	<.001	12	view →
PCPG	DFS	Median	All	0.070	0.936	<.001	6	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
GBM	DFS	Median	All	0.079	0.244	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NR1H4–UCEC (DFS)

Open the UCEC breakdown →