NR1H4

Across TCGA patient cohorts, NR1H4 protein abundance is significantly associated with the RNA expression of many other genes, with 669 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible NR1H4-associated genes across cancer lineages are SEC14L2, APOL4, and TRMU. Each is linked with NR1H4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H4-to-partner and partner-to-NR1H4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NR1H4 versus SEC14L2 in CCRCC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H4→partner) and Y-score (partner→NR1H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEC14L2 →	+0.521	+0.432	<.001	<.001	3	1
CCRCC	APOL4 →	-0.781	-0.455	<.001	<.001	3	1
CCRCC	TRMU →	+0.227	+0.409	.007	.001	3	1
CCRCC	NFATC4 →	-0.508	-0.381	.008	<.001	3	1
CCRCC	PYGB →	+0.455	+0.398	.001	.002	3	1
CCRCC	ZMYND8 →	+0.589	+0.390	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 669 associations by consensus.

NR1H4 vs SEC14L2 — CCRCC

Explore this scatter interactively →