NR1H4

Across TCGA patient cohorts, NR1H4 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NR1H4-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with NR1H4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H4-to-partner and partner-to-NR1H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NR1H4-low versus NR1H4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H4→partner) and Y-score (partner→NR1H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.327	+2.584	.005	.010	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.263	.005	<.001	3	2
UCEC	ERK2 →	+0.171	+1.847	.006	.007	3	2
UCEC	GATA3 →	+0.157	+1.665	.011	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.127	-1.379	.021	.019	3	2
UCEC	MEK1 →	+0.474	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eEF2 by NR1H4 expression — UCEC

Explore this box plot interactively →