NR1H4

Across TCGA cell cohorts, NR1H4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,154 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible NR1H4-associated GO terms across cancer lineages are Positive regulation of amino acid metabolic process, Fatty acid beta-oxidation, and Fatty acid oxidation. Each is linked with NR1H4 in more than 8 cancer types. Because this analysis shows association rather than direction, both NR1H4-to-partner and partner-to-NR1H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of amino acid metabolic process grouped by NR1H4-low versus NR1H4-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H4→partner) and Y-score (partner→NR1H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of amino acid metabolic process →	-0.353	-3.507	<.001	<.001	3	9
LIVER	Fatty acid beta-oxidation →	+0.096	+2.616	<.001	<.001	3	6
LIVER	Fatty acid oxidation →	+0.093	+3.896	<.001	<.001	3	5
LIVER	Lipid oxidation →	+0.087	+3.478	<.001	<.001	3	5
LIVER	Fatty acid metabolic process →	+0.097	+3.954	<.001	<.001	3	5
LIVER	Regulation of membrane depolarization →	+0.083	+2.776	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,154 associations by consensus.

Positive regulation of amino acid metabolic process by NR1H4 expression — KIDNEY

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