NR1H3

Across TCGA cell cohorts, NR1H3 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NR1H3-associated genes across cancer lineages are GPR26, PRY, and PRY2. Each is linked with NR1H3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1H3-to-partner and partner-to-NR1H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by NR1H3-low versus NR1H3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1H3→partner) and Y-score (partner→NR1H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR26 →	+0.016	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRY →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRY2 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NLRP8 →	+0.054	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	ETDC →	+0.513	+5.228	<.001	.005	3	1
BLOOD_Leukemia	BMP5 →	+0.012	+3.771	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

GPR26 by NR1H3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →