NR1D2

Across TCGA cell cohorts, NR1D2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR1D2-associated genes across cancer lineages are ACKR1, TBC1D3, and SIGLEC1. Each is linked with NR1D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR1D2-to-partner and partner-to-NR1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACKR1 grouped by NR1D2-low versus NR1D2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR1D2→partner) and Y-score (partner→NR1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACKR1 →	+0.058	+3.354	<.001	.002	3	1
LARGE_INTESTINE	TBC1D3 →	+0.066	+2.688	<.001	.008	3	1
LARGE_INTESTINE	SIGLEC1 →	+0.113	+3.464	.003	.004	3	1
CNS	SPRR2G →	+0.116	+5.285	<.001	<.001	3	1
CNS	TRIM64B →	+0.531	+4.643	<.001	.003	3	1
CNS	MTRNR2L10 →	+0.012	+5.357	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ACKR1 by NR1D2 expression — LARGE_INTESTINE

Explore this box plot interactively →