NR1D1

Across TCGA pan-cancer cohorts, NR1D1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NR1D1 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NR1D1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NR1D1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

STAD, UCEC, and ESCA are the cancer types where NR1D1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	III,IV	1.000	0.328	.013	17	view →
UCEC	DFS	Median	All	1.000	0.635	.027	6	view →
ESCA	DFS	Median	All	0.146	0.533	.046	3	view →
COAD	DFS	Median	II,III,IV	0.183	0.687	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NR1D1–STAD (DFS)

Open the STAD breakdown →