NR1D1

Across TCGA pan-cancer cohorts, NR1D1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NR1D1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NR1D1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NR1D1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where NR1D1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.766	.047	4	view →
PDAC	DFS	Tertile	All	0.205	0.532	.020	4	view →
LUAD	DFS	Quartile	All	0.223	0.743	.024	3	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.847	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NR1D1–LSCC (DFS)

Open the LSCC breakdown →