NPVF

Across TCGA patient cohorts, NPVF mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPVF-associated genes across cancer lineages are RN7SL248P, EZH2P1, and RNA5SP300. Each is linked with NPVF in more than 1 cancer types. Because this analysis shows association rather than direction, both NPVF-to-partner and partner-to-NPVF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by NPVF-low versus NPVF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPVF→partner) and Y-score (partner→NPVF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.112	+4.137	<.001	<.001	3	2
UCEC	EZH2P1 →	+0.422	+3.486	<.001	<.001	3	2
BRCA	RNA5SP300 →	+0.481	+5.646	<.001	.004	3	2
SKCM	RNU6-433P →	+0.351	+4.495	<.001	.007	3	2
SKCM	RNU6-905P →	+0.365	+5.098	<.001	<.001	3	2
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

RN7SL248P by NPVF expression — UCEC

Explore this box plot interactively →